Ovarian Rejuvenation Using Autologous Platelet-Rich Plasma

Advanced maternal age is associated with the natural oocyte depletion, leading to low yield, high infertility treatment cancellation rates, and eventual decreases in pregnancy rates. Various innovative interventions have been introduced improve outcome of for aging patients. Numerous published data demonstrated that early follicle development was regulated by intraovarian growth factors through autocrine or paracrine mechanisms. Platelet-rich plasma (PRP), a fraction peripheral blood concentration platelets, has implemented regenerative medicine last decade. The contains variety were suggested be able enhance angiogenesis regeneration cell proliferation process. initial report showed an injection PRP improved hormonal profile increased number retrieved oocytes patients diminished ovarian reserve. Subsequently, several studies larger sample sizes reported this approach resulted healthy live births no apparent complications. However, use needs fully investigated, because randomized controlled trial yet performed confirm its efficacy.